When updating Exchange servers remember that since 2010 era they no longer automatically MU down.
To know what the latest and greatest is – check out this post:
For an oneoff clicking on help-about is probably the easiest.
Then compare it to this list here: https://technet.microsoft.com/library/hh135098.aspx?f=255&MSPPError=-2147217396
Then keep in mind for Exchange 2010 if you do any PCI/TLS tweaking that you need to be on update rollup 9 as noted here:
SMTP is not transported over TLS 1.1 or TLS 1.2 protocol in an Exchange Server 2010 environment: